The rapid digital transformation of healthcare has expanded the reach of telehealth, yet its benefits remain unevenly distributed across low-income, rural, and racially and ethnically marginalized populations. For these groups, persistent gaps in broadband access, digital literacy, and culturally responsive care risk reproducing and in some cases amplifying existing health disparities. Telehealth therefore represents not only a technological innovation but also a critical equity test: its effectiveness depends on how systems are designed, implemented, and supported. This systematic literature review examines how telehealth interventions influence healthcare access, engagement, and clinical outcomes among vulnerable populations, and under what conditions these interventions meaningfully reduce disparities rather than reinforce them, beyond public health outcomes, this review frames telehealth as a socio-technical system whose performance is shaped by infrastructure, interface design, and user-system interaction. Guided by the Digital Divide Framework and conducted in accordance with PRISMA guidelines, the review synthesizes peer-reviewed studies published between 2015 and 2025 across PubMed, Scopus, and CINAHL. Data extraction and quality appraisal, using the Mixed Methods Appraisal Tool (MMAT), focus on telehealth modality, population characteristics, digital access constraints, literacy and navigation supports, and outcome domains including access, adherence, and health improvement. Comparative synthesis evaluates the equity performance of video-based care, mobile health applications, and remote patient monitoring relative to traditional in-person services. Preliminary findings indicate that telehealth interventions are most effective in reducing disparities when paired with digital literacy support, connectivity assistance, and culturally responsive workflows. Anticipated contributions include an equity-oriented typology of telehealth strategies, identification of contextual enablers and failure points, and evidence-based design principles that frame telehealth equity as a systems-level engineering and policy challenge. The findings inform engineering design considerations for equitable telehealth systems, including human-centered interfaces, scalable infrastructure, and competency-aligned workforce training. By positioning equity as a core design requirement rather than a downstream consideration, this review informs future research, system design, and engineering practice in equitable health technology implementation.
http://orcid.org/https://0000-0002-8521-5769
Morgan State University
[biography]
The full paper will be available to logged in and registered conference attendees once the conference starts on June 21, 2026, and to all visitors after the conference ends on June 24, 2026