Engineers may be regarded for their technical knowledge and creative solutions, but these skills are just as important for entrepreneurs to make strategic decisions for an organization. Engineers and entrepreneurs seek out opportunities, secure and employ resources, and provide leadership to create something of value. Engineers may lack entrepreneurship development and exposure due to curricula focused on technical content, but these very skills and mindset can be developed. A culture of coachability is a key factor in creating successful, fundable ventures. The Center for Medical Innovation’s Innovation Fellows (IF) Program has developed a distinctive mentoring strategy to nurture innovation and engineering entrepreneurial mindsets in early-career engineers and scientists. This year-long program enhances expertise in engineering, life sciences, and clinical disciplines with additional training in key commercialization areas and provides multi-perspective mentorship to advance translational research and bring novel medical technologies to the marketplace.